:root{--paper:#f6f2ea;--ink:#252a42;--muted:#62616d;--line:#ded5d4;--accent:#d87964}*{box-sizing:border-box}body{margin:0;background:var(--paper);color:var(--ink);font-family:Arial,Helvetica,sans-serif;font-size:16px;line-height:1.7}a{color:inherit;text-decoration:none}a:focus-visible{outline:3px solid #be6c38;outline-offset:6px}.skip{position:absolute;top:-100px;background:white;padding:12px}.skip:focus{top:0;z-index:9}.preview{background:#f2ded5;text-align:center;padding:7px 16px;font-size:10px;letter-spacing:.13em}header,main,footer{max-width:1280px;margin:auto}header{display:flex;align-items:center;justify-content:space-between;padding:30px 48px;border-bottom:1px solid var(--line)}.brand{font-family:Georgia,serif;font-size:26px;letter-spacing:-.8px}.brand span{display:block;font-family:Arial,sans-serif;font-size:9px;letter-spacing:.19em;margin-top:3px}nav{display:flex;gap:30px;font-size:13px}nav a:hover,nav a[aria-current]{text-decoration:underline;text-underline-offset:8px}main{padding:0 48px 80px}.hero{display:grid;grid-template-columns:1.2fr 1fr;gap:60px;padding:75px 0 65px;align-items:center}.eyebrow{font-size:10px;font-weight:600;letter-spacing:.18em;margin:0 0 25px}h1,h2,h3{font-family:Georgia,'Times New Roman',serif;font-weight:400;line-height:1.08;letter-spacing:-.045em}h1{font-size:clamp(54px,6.7vw,88px);margin:0 0 28px}em{font-weight:400;color:#a44735}h2{font-size:44px;margin:0 0 25px}h3{font-size:30px;margin:0 0 10px}.lead{color:var(--muted);font-size:17px;max-width:490px;line-height:1.8}.actions{display:flex;align-items:center;gap:26px;margin-top:30px}.button{display:inline-flex;gap:25px;align-items:center;background:var(--ink);color:white;padding:14px 20px;font-size:12px}.button:hover{background:#a44735}.text-link{font-size:12px;border-bottom:1px solid #bd7966;padding-bottom:4px}.science-art{background:var(--ink);border-radius:50% 50% 2px 2px;overflow:hidden;position:relative;aspect-ratio:1/1.15;display:flex;flex-direction:column;justify-content:center}.science-art svg{width:100%;height:auto}.science-art span{color:#ead6e1;font-size:10px;text-align:center;letter-spacing:.08em;padding:10px 0 30px}.credential{display:flex;gap:28px;align-items:center;border-top:1px solid var(--line);border-bottom:1px solid var(--line);padding:24px 0;font-size:12px}.credential>span:first-child{font-size:9px;letter-spacing:.13em;margin-right:auto}.credential strong{font-weight:500}.intro{display:grid;grid-template-columns:1fr 1.6fr;column-gap:70px;padding:80px 0 50px}.intro .eyebrow{grid-column:1/-1}.intro p:last-child{color:var(--muted);max-width:450px;margin:0}.directory{border-top:1px solid var(--line)}.directory>a{display:flex;align-items:center;gap:35px;border-bottom:1px solid var(--line);padding:30px 5px}.directory>a:hover{background:#f2ded5}.number{font-size:11px;color:#a44735;align-self:flex-start;padding-top:6px}.directory p{margin:0;font-size:14px;color:var(--muted)}.arrow{margin-left:auto;font-size:28px}footer{border-top:1px solid var(--line);padding:35px 48px;display:flex;align-items:center;gap:40px;font-size:11px;color:var(--muted)}footer p{margin-right:auto}footer .brand{color:var(--ink);font-size:22px}.page-heading{padding:80px 0 65px;border-bottom:1px solid var(--line)}.page-heading h1{font-size:clamp(50px,6vw,76px)}.split{display:grid;grid-template-columns:1fr 1fr;gap:70px;padding:60px 0;border-bottom:1px solid var(--line)}.split h2{font-size:36px}.split p{margin-top:0;color:var(--muted)}.empty{padding:65px 0;max-width:650px}.empty h2{font-size:34px}.empty p,.prose p{color:var(--muted)}.entry{padding:40px 0;border-bottom:1px solid var(--line)}.prose{max-width:700px;padding:50px 0}.prose h2{font-size:28px;margin-top:30px}.profile{display:block;padding:12px 0;border-bottom:1px solid var(--line)}@media(max-width:760px){header{padding:23px 24px;flex-wrap:wrap;gap:22px}nav{gap:25px;width:100%;justify-content:space-between}main{padding:0 24px 50px}.hero{grid-template-columns:1fr;padding:45px 0;gap:40px}.science-art{max-width:440px;width:100%;margin:auto;aspect-ratio:1.1}.credential{flex-wrap:wrap;gap:8px 24px}.credential>span:first-child{width:100%}.intro,.split{grid-template-columns:1fr;gap:18px;padding:45px 0}h2{font-size:36px}.actions{gap:20px;flex-wrap:wrap}.directory>a{gap:20px}.directory h3{font-size:27px}footer{padding:30px 24px;flex-wrap:wrap;gap:20px}footer p{width:50%;margin:0}footer>span{margin-left:auto}.page-heading{padding:50px 0 35px}}@media(prefers-reduced-motion:no-preference){a{transition:background .2s ease,color .2s ease}}@media print{.preview,nav,.skip{display:none}body{background:white}.science-art{max-width:250px}header,main,footer{padding:20px}}

/* Scientific background: editorial narrative */
.profile-hero{padding:72px 0 58px;max-width:920px}.profile-hero h1{font-size:clamp(56px,7.5vw,96px);line-height:1.01;margin-bottom:30px}.profile-deck{font-size:20px;line-height:1.65;max-width:640px;color:var(--muted)}.profile-story{display:grid;grid-template-columns:1fr 2fr;gap:70px;border-top:1px solid var(--line);padding:48px 0 64px}.story-note .eyebrow{font-size:9px}.story-note p{font-family:Georgia,serif;font-size:23px;line-height:1.4;margin-top:20px}.story-copy{max-width:650px}.story-copy p{font-size:17px;line-height:1.9;margin:0 0 22px;color:#505061}.story-copy p:last-child{margin-bottom:0}.study-path{display:grid;grid-template-columns:repeat(3,1fr);background:#f0e1d8;padding:36px 30px;gap:28px}.study-path article+article{border-left:1px solid #d7c7ce;padding-left:28px}.path-number{font-size:9px;letter-spacing:.12em}.study-path h2{font-size:29px;line-height:1.15;letter-spacing:-.035em;margin:24px 0 20px}.study-path p{font-size:13px;line-height:1.8;color:#62616d;margin:0}.profile-close{display:grid;grid-template-columns:1fr 1fr;gap:70px;padding:62px 0;border-bottom:1px solid var(--line)}.profile-close h2{font-size:33px;line-height:1.15;margin:0}.profile-close>p{align-self:center;color:var(--muted);margin:0;font-size:16px}.profile-links{padding:35px 0 0}.profile-links>div{display:flex;gap:24px;flex-wrap:wrap}.profile-links .profile{font-size:12px;border:0;padding:0}.profile-links .eyebrow{margin-bottom:14px}@media(max-width:760px){.profile-hero{padding:48px 0 35px}.profile-deck{font-size:18px}.profile-story{grid-template-columns:1fr;gap:22px;padding:32px 0 40px}.story-note p{margin:10px 0 0}.story-copy p{font-size:16px}.study-path{grid-template-columns:1fr;padding:28px;gap:26px}.study-path article+article{border-left:0;border-top:1px solid #d7c7ce;padding:26px 0 0}.study-path h2{margin:14px 0;font-size:28px}.profile-close{grid-template-columns:1fr;gap:25px;padding:40px 0}.profile-close h2{font-size:30px}}

/* Connected scientific perspective */
.study-path{display:block;padding:44px 40px;background:#f0e1d8}.path-intro{display:grid;grid-template-columns:1fr 1fr;gap:0 55px;padding-bottom:32px}.path-intro .eyebrow{grid-column:1/-1;margin-bottom:18px}.study-path .path-intro h2{font-size:38px;line-height:1.1;margin:0}.path-intro>p:last-child{font-size:15px;max-width:470px;align-self:center}.study-path article,.study-path article+article{display:grid;grid-template-columns:1fr 1.6fr;gap:45px;border:0;border-top:1px solid #d7c7ce;padding:32px 0;margin:0}.study-path article:last-child{padding-bottom:0}.study-path .path-title h2{font-size:29px;line-height:1.15;margin:18px 0 0}.study-path .path-detail p{font-size:15px;line-height:1.8;margin:0 0 17px;max-width:610px}.path-connection{display:block;font-size:9px;line-height:1.8;letter-spacing:.1em;color:#a44735;padding-top:4px}@media(max-width:760px){.study-path{padding:30px 25px}.path-intro{grid-template-columns:1fr;gap:20px;padding-bottom:25px}.study-path .path-intro h2{font-size:33px}.path-intro .eyebrow{margin-bottom:0}.study-path article,.study-path article+article{grid-template-columns:1fr;gap:20px;padding:28px 0}.study-path .path-title h2{font-size:28px;margin-top:12px}.study-path .path-detail p{font-size:15px}}

.research-project{display:grid;grid-template-columns:55px 1fr;gap:25px;padding:42px 0;border-bottom:1px solid var(--line)}.project-index{font-family:Georgia,serif;font-size:25px;color:#a44735}.research-project .eyebrow{margin-bottom:15px}.research-project h2{font-size:36px;max-width:850px;line-height:1.16;margin-bottom:20px}.research-project p:not(.eyebrow){max-width:760px;color:var(--muted);font-size:16px;line-height:1.85}.research-project .project-focus{font-size:11px!important;color:var(--ink)!important;border-top:1px solid var(--line);padding-top:16px;margin-top:24px}@media(max-width:760px){.research-project{grid-template-columns:30px 1fr;gap:15px;padding:30px 0}.research-project h2{font-size:28px}.research-project p:not(.eyebrow){font-size:15px}.research-project .eyebrow{font-size:9px}}

/* Portrait and shirt-inspired color palette */
.about-hero{display:grid;grid-template-columns:1.15fr 1fr;gap:65px;align-items:center;padding:65px 0}.about-hero h1{font-size:clamp(48px,5.5vw,74px)}.portrait{margin:0;align-self:center}.portrait img{display:block;width:100%;height:auto;aspect-ratio:4/5;object-fit:cover;object-position:50% 50%;border-radius:160px 160px 3px 3px}.portrait figcaption{border-top:3px solid #d87964;margin-top:20px;padding-top:13px;font-size:10px;letter-spacing:.13em}.portrait figcaption span{display:block;color:var(--muted);font-size:11px;letter-spacing:0;margin-top:5px}.eyebrow{color:#a44735}a:focus-visible{outline-color:#a44735}@media(max-width:760px){.about-hero{grid-template-columns:1fr;gap:30px;padding:45px 0}.portrait{max-width:420px;width:100%;margin:auto}.about-hero h1{font-size:clamp(47px,9vw,65px)}}

/* Coral leads the accent palette; navy anchors the typography. */
h1 em,h2 em{color:#b64f3c}.eyebrow,.project-index,.path-number,.number{color:#a44735}.preview{background:#f0d4c8}.portrait figcaption{border-top-color:#d87964}.text-link{border-bottom-color:#cb8069}.button{background:#a44735}.button:hover{background:#873b2d}

.science-article{max-width:850px;margin:0 auto}.article-heading{padding:65px 0 30px}.article-heading>.text-link{display:inline-block;margin-bottom:35px}.article-heading h1{font-size:clamp(38px,5vw,62px);line-height:1.12;letter-spacing:-.035em}.article-heading .lead{max-width:720px;font-size:19px}.byline{font-size:13px;color:var(--muted)}.byline a{text-decoration:underline;text-underline-offset:4px}.article-contents{border-block:1px solid var(--line);padding:18px 0}.article-contents summary{cursor:pointer;color:#a44735;font-size:14px}.article-contents nav{display:grid;gap:10px;padding:20px 0 5px;width:auto}.article-contents a{font-size:13px}.article-body{max-width:700px;margin:40px auto;font-family:Georgia,serif;font-size:19px;line-height:1.85}.article-body p{margin:0 0 23px}.article-body em{color:inherit}.article-body h2{font-size:34px;line-height:1.22;letter-spacing:-.025em;margin:55px 0 25px;scroll-margin-top:30px}.article-body h3{font-size:25px;line-height:1.3;margin:32px 0 18px}.equation{background:#f0e1d8;padding:20px;text-align:center;overflow-wrap:anywhere}.references{font-family:Arial,sans-serif;font-size:13px;line-height:1.8;padding-left:25px;overflow-wrap:anywhere}.references li{margin-bottom:18px}.article-author{border-top:1px solid var(--line);margin-top:45px;font-family:Arial,sans-serif;font-size:15px}.article-author h2{font-size:28px}.article-source{border-top:1px solid var(--line);padding:24px 0;font-size:12px}.article-source a{text-decoration:underline}@media(max-width:760px){.article-heading{padding-top:40px}.article-body{font-size:18px}.article-body h2{font-size:29px}.article-heading .lead{font-size:17px}}

.article-series{font-family:Georgia,serif;font-size:23px;color:#a44735}.fentanyl-equation{background:#f0e1d8;padding:22px 12px;margin:28px 0;overflow-x:auto}.fentanyl-equation math{font-size:1.1em}.article-body math{color:inherit}math mi[mathvariant="normal"]{font-style:normal}

.fentanyl-series-nav{display:flex;gap:20px;border-block:1px solid var(--line);padding:24px 0;margin-top:40px;font-size:15px}.fentanyl-series-nav a{color:#a44735;max-width:650px}.equation-definitions{padding-left:24px}.equation-definitions li{margin-bottom:12px}.fentanyl-equation math{max-width:100%}@media(max-width:760px){.fentanyl-series-nav{width:100%;font-size:14px}}

.fentanyl-series-nav{flex-wrap:wrap}@media(max-width:760px){.mass-balance-equation math{font-size:.92em}}

.pbpk-table-wrap{margin:30px 0;overflow-x:auto}.pbpk-table{width:100%;border-collapse:collapse;font-family:Arial,sans-serif;font-size:15px;line-height:1.6}.pbpk-table th,.pbpk-table td{text-align:left;vertical-align:top;padding:14px 12px;border-bottom:1px solid var(--line)}.pbpk-table th{background:#f0e1d8;color:var(--ink)}@media(max-width:760px){.pbpk-table{font-size:13px}.pbpk-table th,.pbpk-table td{padding:10px 8px}}

.boxed-equation math{border:1px solid var(--ink);padding:12px 8px;border-radius:2px}