RESEARCH & PROJECTS
Selected work connecting molecular interactions, drug disposition, toxicology, and the decisions that shape drug development.
SELF-DIRECTED RESEARCH
Investigating fentanyl pharmacokinetics through adipose tissue sequestration and delayed systemic release. The project combines literature-derived ADME parameters with physiologically based pharmacokinetic (PBPK) modeling to explore lipophilicity, tissue distribution, and the hypothesis of re-intoxication following rapid weight loss.
Pharmacokinetics · PBPK modeling · Drug distribution
EXPLORATORY COMPUTATIONAL CHEMISTRY
Exploring opioid ligand binding and predicted pharmacokinetic properties through molecular docking and cheminformatics. The work connects structure–activity relationships with predicted absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles to examine how molecular features may influence biological activity.
Molecular docking · Cheminformatics · ADMET prediction
CONCEPTUAL FRAMEWORK
A framework connecting medicinal chemistry optimization, physiologically based pharmacokinetic modeling, and regulatory strategy early in drug development. It explores how these disciplines can inform one another when evaluating the path from a promising molecule to a development candidate.
Medicinal chemistry · PBPK modeling · Regulatory strategy
REGULATORY RESEARCH
Examining clinical trial reporting requirements under ClinicalTrials.gov and related transparency policies. The analysis considers how reporting standards shape drug development oversight and regulatory compliance.
Clinical trial transparency · Regulatory science · Reporting standards