SCIENCE WRITING
How Does Naloxone Reverse a Fentanyl Overdose?
Explore how naloxone reverses fentanyl toxicity through competitive μ-opioid receptor antagonism, receptor occupancy, pharmacokinetics, and respiratory recovery.
THE SCIENCE BLOG
Ideas worth
examining.
Scientific writing, with space for complexity.
SCIENCE WRITING
How Does Fentanyl Stop Someone From Breathing?
Explore how fentanyl suppresses breathing through μ-opioid receptors, brainstem respiratory networks, impaired carbon dioxide responses, and respiratory failure.
SCIENCE WRITING
Why Is Fentanyl So Potent?
Explore the molecular pharmacology of fentanyl, including μ-opioid receptor binding, intrinsic efficacy, receptor reserve, G protein signaling, and pharmacological potency.
SCIENCE WRITING
How Do Toxicologists Measure Fentanyl in Blood and Urine?
How scientists identify and quantify fentanyl and norfentanyl using LC-MS/MS, including sample preparation, calibration, method validation, and forensic interpretation.
SCIENCE WRITING
Can We Predict Where Fentanyl Goes in the Human Body?
Explore how scientists use physiologically based pharmacokinetic models to predict fentanyl distribution, hepatic metabolism, tissue accumulation, and elimination.
SCIENCE WRITING
Can Fentanyl Stored in Fat Cause Delayed Toxicity?
An evidence-based examination of fentanyl redistribution, recurrent opioid toxicity, adipose tissue pharmacokinetics, and the unproven hypothesis of weight-loss-induced reintoxication.
SCIENCE WRITING
What Happens to Fentanyl After It Enters the Bloodstream?
Explore fentanyl pharmacokinetics, including tissue redistribution, CYP3A4 metabolism, hepatic clearance, elimination half-life, and context-sensitive recovery.
SCIENCE WRITING
Why Does Fentanyl Accumulate in Fat?
How lipophilicity, ionization, tissue perfusion, and exposure duration shape fentanyl distribution into adipose tissue.
SCIENCE WRITING
What Happens to a Drug After You Take It? A Molecular Journey Through the Human Body
Understanding how medications are absorbed, distributed, metabolized, and eliminated—and why these processes determine how drugs work.
SCIENCE WRITING
Joseph Paul Calihan — Medicinal Chemistry, Pharmaceutical Chemistry, Biochemistry & Pharmacology
An introduction to my scientific interests and professional profiles. Published on Medium.